慢性鼻炎与成年人的反流性疾病之间的关联:系统性审查和元分析
Ahmad Aldajani1,2, Fahad Alhussain3, Tamer Mesallam1
1Department of Otorhinolaryngology Head & Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
American journal of rhinology & allergy
|November 1, 2023
概括
胃食道逆流性疾病 (GERD) 与慢性鼻炎 (CRS) 有显著的关联,许多患者通过质子抑制剂 (PPI) 治疗得到改善. 需要进一步的研究来证实这种联系.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 医学研究 医学研究
背景情况:
- 反流性疾病,包括喉回流 (LPR) 和胃食道反流病 (GERD),与上空消化道炎症有关.
- 确定反流和慢性鼻炎 (CRS) 之间的明确联系是复杂的,因为它们的高患病率和潜在的同时发生.
研究的目的:
- 系统地审查和评估科学文献,寻找连接反流性疾病和CRS的证据.
- 评估GERD,LPR和CRS之间的关联的强度.
主要方法:
- 在主要数据库中对1950年至2022年间发表的研究进行了全面的文献搜索.
- 包括英语成人研究,不包括病例报告和系列. 使用标准化工具评估了偏差风险.
主要成果:
- 在 427 篇已识别的文章中,有 25 项研究研究了反流-CRS 关系.
- 在GERD和CRS之间发现了显著的关联 (P<.001).
- CRS患者的pH和pepsin水平较高;93%的人通过质子抑制剂 (PPI) 治疗得到改善.
结论:
- 目前的文献表明,在患病率和治疗反应方面,反流性疾病和CRS之间存在相关性.
- 需要进一步的研究来巩固对这种关系的理解.
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