在儿童患者中用双酸盐治疗的登诺苏马布诱导的反弹性高热血症
Anne Gandolfi1, Sarah Shaaban2
1Department of Pediatrics, Rush University Medical Center, Rush Pediatric Residency Program, Chicago, IL 60612, USA.
JCEM case reports
|November 1, 2023
概括
反弹性高血症是儿科患者服用登苏马布 (RANK-L抑制剂) 的副作用之一. 长期起作用的双酸盐索莱德龙酸在儿童病例中有效控制了复发性高热血症.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 丹诺苏马布是一种RANK-L抑制剂,用于非标签的儿科骨疾病,如动脉瘤骨囊 (ABC).
- 反弹性高血症是denosumab的一个公认的,常见的副作用,特别是在儿科患者中.
- 目前针对德诺苏马布诱导的高血症的管理策略缺乏确定的指导方针.
研究的目的:
- 报告小儿科患者在denosumab治疗后出现复发性反弹性高热血症的病例.
- 为了强调denosumab治疗在骨不成熟的个体中越来越多地被认可的副作用.
- 提出一种潜在的治疗方法来管理德诺苏马布诱导的反弹高热血症.
主要方法:
- 一个10岁的女性患有神圣ABC的病例报告,接受了denosumab的治疗.
- 观察复发性高血症发作,从停止登苏马布治疗后3个月开始.
- 在第三次因高血症住院治疗后,用龙酸治疗.
主要成果:
- 患者在停止服用德诺苏马布后经历了反弹性高血症的反复发作.
- 在用佐勒龙酸治疗后,达到正常血症.
- 这表明长效双酸盐在控制这种副作用方面可能发挥作用.
结论:
- 德诺苏马布诱导的反弹性高热血症是儿科患者的一个重大问题.
- 长期作用的双酸盐,如乙烯酸,可能提供一种有效的治疗策略.
- 需要进一步的研究,以制定明确的指导方针来管理这种不良事件.
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