异形 (科布纳) 现象诱导的胰岛素模拟注射在牛皮
Saartje Thijs1, Eric Balti1, Corinne Degraeve2
1Department of Diabetes and Endocrinology, VITAZ Hospital, Sint-Niklaas, Belgium.
JCEM case reports
|November 1, 2023
概括
科布纳现象是一种不常见的皮肤反应,可在糖尿病患者的胰岛素注射部位发生. 这一案例显示了在牛皮发作和用胰岛素类似物治疗期间出现的同型反应.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 科布纳现象或等态反应是一种皮肤反应,可以发生在各种皮肤病症中.
- 它是糖尿病患者皮下胰岛素注射的罕见并发症.
- 以前的报道描述了这种现象在诸如白风,平坦和牛皮等疾病中.
研究的目的:
- 报告2型糖尿病患者中Köbner现象的一个独特病例.
- 要强调这种现象在特定的治疗和疾病条件下发生.
- 强调在高危患者中检查注射部位的重要性.
主要方法:
- 一个56岁的女性患有2型糖尿病的病例报告.
- 在胰岛素注射部位观察皮肤病变.
- 对不同治疗方法 (guselkumab 和 ciclosporin) 的损伤反应的评估.
主要成果:
- 患者在胰岛素注射部位上形成了明显的红血状状斑块,与科布纳现象一致.
- 病变出现在治疗牛皮的甲状腺取消后和牛皮发作期间.
- 这些病变对guselkumab (一种IL-23抑制剂) 有好反应,但对环素没有好反应.
- 这种表现不同于之前的报道,发生在胰岛素类似物和牛皮发作期间.
结论:
- 科布纳现象可以在胰岛素注射部位表现出来,甚至在胰岛素类型和活跃牛皮期间.
- 对于使用持续血糖监测或胰岛素治疗的患者来说,彻底检查注射/插入部位至关重要.
- 这一案例扩大了对糖尿病患者科布纳现象触发因素和表现的理解.
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