慢性肝衰竭的急性:一个南澳大利亚的经验
Shauna Madigan1,2, Yasmina Tashkent1,2, Sharad Trehan3
1Department of Gastroenterology and Hepatology Flinders Medical Centre Bedford Park South Australia Australia.
JGH open : an open access journal of gastroenterology and hepatology
|November 1, 2023
概括
慢性肝衰竭 (ACLF) 的急性肝衰竭在澳大利亚肝硬化和急性衰退患者中很常见,导致高死亡率. 解决酒精使用障碍对于肝移植资格和改善生存率至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 关键护理医学 关键护理医学
背景情况:
- 慢性肝衰竭急性 (ACLF) 是一种严重的综合征,在肝硬化患者急性失补偿 (AD).
- 高死亡率需要改进的管理策略,包括肝移植 (LT).
- 澳大利亚关于ACLF患病率和结果的数据有限.
研究的目的:
- 确定澳大利亚住院患者中ACLF的患病率,临床概况和结果.
- 分析患者的特征,临床过程和生存率.
- 评估肝移植在ACLF患者中的可行性.
主要方法:
- 追溯审查从2017-2019年肝病学入院的病例.
- 使用欧洲肝脏研究协会的标准定义了AD和ACLF队列.
- 分析了患者人口统计,临床数据,28日和90天的存活率,以及LT评估.
主要成果:
- 在192例AD入院中的74例 (39%) 符合ACLF标准.
- 与酒精有关的肝硬化是普遍存在的;功能衰竭是最常见的器官衰竭.
- 在ACLF患者中,28天 (23%对2%) 和90天 (36%对16%) 的死亡率显著增加.
结论:
- 澳大利亚肝硬化患者患有AD的ACLF普遍存在,并与高死亡率相关.
- 酒精使用障碍 (AUD) 是对LT评估的一个重要障碍.
- 优先考虑ACLF患者进行LT后AUD治疗可能会改善存活率,因此需要进行前性研究.
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