日本COVID-19中的血栓形成和抗脂抗体:基于倾向性得分匹配的结果
Seiya Oba1, Tadashi Hosoya1, Risa Kaneshige2
1Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Frontiers in immunology
|November 1, 2023
概括
抗脂抗体 (aPL) 在COVID-19患者中很常见,但不能预测血栓形成. COVID-19患者的β-2葡萄糖蛋白I (β2GPI) 水平比健康个体低,不论血栓形成.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血栓形成是COVID-19的一个重要并发症.
- 抗脂抗体 (aPL) 在COVID-19患者中被检测到,但它们在血栓形成中的作用尚不清楚.
- 贝塔-2糖蛋白I (β2GPI) 是aPL的一个关键抗原.
研究的目的:
- 评估aPL在日本COVID-19患者的患病率和临床意义,有或没有血栓形成.
- 为了比较COVID-19患者的血清β2GPI度有或没有血栓形成,以及与健康的捐赠者.
主要方法:
- 对594名住院COVID-19患者进行了回顾性,单中心,嵌套的病例控制研究.
- 倾向性得分匹配 (PSM) 用于比较aPL流行/titer和血栓形成和非血栓形成组之间的β2GPI水平.
- 此外,PSM还用于比较COVID-19患者和健康捐赠者之间的β2GPI水平.
主要成果:
- 在有或没有血栓形成的COVID-19患者之间没有观察到aPL患病率或标位的显著差异.
- 与健康捐赠者相比,COVID-19患者的血清β2GPI水平较低.
- 血清β2GPI水平在COVID-19患者与没有血栓形成之间没有差异.
结论:
- aPL的患病率和标位与日本COVID-19患者的血栓性并发症无关.
- COVID-19与血清β2GPI水平降低有关,独立于血栓形成.
- 在aPL阳性COVID-19患者中,需要进一步监测长期的血栓栓塞风险和抗脂综合征 (APS).
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