在儿童中,肺功能受损与动脉内膜介质厚度之间存在关联
Talha Rafiq1, Koon K Teo2,3,4, Katherine M Morrison5,6
1Medical Sciences Graduate Program, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
ERJ open research
|November 1, 2023
概括
儿童阻塞性肺病与较厚的动脉壁有关,这表明早期心血管疾病的风险. 这种联系表明,年轻人的肺部健康影响了长期的心脏健康.
科学领域:
- 儿科医学 儿科医学
- 心血管健康 心血管健康
- 肺部病理学 肺部病理学
背景情况:
- 心血管疾病 (CVD) 风险因素通常从童年到成年期都能追踪到.
- 阻塞性肺病越来越多地被认为是导致心血管疾病的潜在原因.
- 影响肺功能和心血管健康的早期生活因素需要进一步调查.
研究的目的:
- 调查阻塞性肺功能障碍与儿童期亚临床心血管变化之间的关联.
- 为了确定这种关联是否在控制已确定的心血管风险因素后仍然存在.
主要方法:
- 横截面研究设计. 截面研究设计.
- 使用螺旋计测试来评估肺功能,以确定阻塞性模式.
- 测量动脉内心介质厚度 (cIMT) 作为亚临床动脉样硬化的标志物.
- 统计分析考虑潜在的混因素,如年龄,性别,社会经济地位和生活方式因素.
主要成果:
- 在阻塞性肺功能障碍和儿童中较高的cIMT之间发现了显著的关联.
- 即使调整了常见的心血管风险因素,这种关联仍然明显.
- 这些发现突出了早期肺部健康和血管发育之间的潜在联系.
结论:
- 儿童期阻塞性肺功能障碍与亚临床动脉样硬化有关.
- 这表明一种发展途径将早期肺部疾病与晚期心血管疾病联系起来.
- 针对生命早期肺部健康的干预措施可能具有长期的心血管益处.
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