评估心脏对急性体积变化的反应的非侵入性护理设备
Harry A Silber1, Nisha A Gilotra1, Thomas L Miller2,3
1Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Medical devices (Auckland, N.Z.)
|November 1, 2023
概括
Indicor 设备准确地测量瓦萨尔瓦脉冲响应 (VPR),并检测中央血液体积的变化. 这种非侵入性工具对在床边评估液体状况非常有希望.
科学领域:
- 心血管生理学心血管生理学
- 医疗器械技术 医疗器械技术
- 诊断工具 诊断工具
背景情况:
- 瓦萨尔瓦机动改变了外围脉冲振幅,提供了对体积状态的洞察力.
- 瓦萨尔瓦脉冲响应 (VPR) 的自动定量可以帮助临床评估.
- 一个新的设备,Indicor,旨在标准化和自动化VPR测量.
研究的目的:
- 评估 Indicor 设备的 VPR 测量是否能够检测被动腿部提升 (PLR) 诱导的急性中央体积变化.
- 在标准化的瓦萨尔瓦机动中,评估健康志愿者自动化VPR的灵敏度.
主要方法:
- 健康的志愿者接受了标准化的Valsalva机动,由Indicor设备指导.
- 在10秒的呼气力 (20 mmHg) 过程中记录了光斑缩图 (PPG) 信号.
- 计算VPR是终端Valsalva与基线脉冲振幅的比率.
主要成果:
- 在所有30名参与者中,从基线 (0.34 ± 0.13) 到PLR (0.60 ± 0.14) 的VPR显著增加 (p < 0.0001).
- 在恢复直立时,与PLR (p < 0.0001) 相比,VPR显著下降 (0.33 ± 0.10).
- 该设备通过PLR证明了对急性中央体积负荷的敏感性.
结论:
- 在标准化的瓦萨尔瓦机动中,Indicor设备可靠地和自动地使用PPG在标准化的瓦萨尔瓦机动中量化VPR.
- 自动VPR测量对健康个体中PLR中枢体积负载的急剧增加敏感.
- 需要进一步的研究来探索心力衰竭和改变液体状况的患者群体中的VPR.
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