代谢健康的肥胖不是一个神话
Sarah S Farabi1,2, Gordon I Smith1, Jun Yoshino1,3
1Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.
JCEM case reports
|November 1, 2023
概括
在某些个体中,尽管体重显著增加,但代谢健康的肥胖 (MHO) 可能会持续存在. 这项案例研究表明,一个患有MHO的女性在增加30.8公斤后仍然在代谢上保持健康.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 代谢健康的肥胖症 (MHO) 是由缺乏代谢综合征成分来定义的.
- 与MHO相关的长期存在和心脏代谢风险仍在争论中.
- 这项研究检查了五年来严格定义的MHO病例,显著增加体重.
研究的目的:
- 为了研究在单个个体中经历大量体重增加的代谢健康肥胖症 (MHO) 的持续性.
- 评估显著体重增加对MHO患者心脏代谢参数的影响.
- 探索与MHO中体重增加相关的脂肪组织中的分子变化.
主要方法:
- 一个25岁妇女的长度案例研究,严格定义的MHO.
- 评估代谢参数,包括口服葡萄糖耐受性,胰岛素敏感性 (高胰岛素血糖-高血糖),血甘油三和肝脏内甘油三含量.
- 分析身体质量指数 (BMI),动脉内膜介质厚度,脂肪组织基因表达 (细胞外基质,炎症) 和血细胞因子度 (IL-6,C反应蛋白).
主要成果:
- 尽管体重增加了32% (BMI从37.7kg/m2增加到49.6kg/m2),但该人保持了正常的葡萄糖耐受性,胰岛素敏感性和甘油三水平.
- 没有观察到禁食葡萄糖,β细胞功能或动脉内膜-介质厚度的不良变化.
- 脂肪组织炎症基因表达增加,但血细胞因子水平只增加了IL-6和C反应蛋白.
结论:
- 这项案例研究表明,尽管体重增加显著,但一些肥胖的人可能会对不良心脏代谢效应表现出抵抗力.
- 这些发现挑战了所有肥胖个体心脏代谢风险增加的普遍假设.
- 需要进一步的研究,以了解这种肥胖的代谢弹性背后的机制.
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