降脂后高残留心血管风险:预测性,预防性,个性化,参与性和精神认知医学的黄金时间
E Reijnders1, A van der Laarse1, J W Jukema2,3
1Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Frontiers in cardiovascular medicine
|November 1, 2023
概括
尽量减少残留心血管疾病 (CVD) 风险,包括解决他类药物治疗,高密度脂蛋白胆固醇 (HDL-C),甘油三 (TG) 水平,和新兴因素,如脂蛋白. 需要一个整体的P5医学方法来实现个性化的患者管理.
科学领域:
- 心脏病学 心脏病学
- 预防医学 预防医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 尽管降脂疗法的进展,残留心血管疾病 (CVD) 风险仍然是一个重大挑战.
- 目前的管理往往只关注单一的风险因素,需要更广泛的视角.
研究的目的:
- 审查和综合关于残留心血管疾病风险的文献.
- 确定心血管疾病的不断变化的风险因素和治疗策略.
- 在心血管疾病管理中倡导转向个性化,P5医学的范式转变.
主要方法:
- 对989篇关于残留心血管疾病风险的论文进行系统性文献审查.
- 分析研究趋势,从他类药物治疗到新的脂质标.
- 识别新出现的风险因素和治疗干预措施.
主要成果:
- 最初的研究重点是他类药物,高密度脂蛋白胆固醇 (HDL-C) 和甘油三 (TG) 水平.
- 新出现的危险因素包括高脂蛋白残留物和脂蛋白 (a) [Lp (a) ].
- 持续发现风险因素和治疗方法有望进一步降低残留心血管疾病风险.
结论:
- 整体的P5医学方法 (预测,预防,个性化,参与,心理认知) 对于优化患者管理至关重要.
- 根据个体心血管疾病风险因素和脂质状况量身定制的个性化治疗策略至关重要.
- 该领域正在朝着更全面和个性化的方法来减少心血管疾病风险的方向发展.
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