在COVID-19患者的心肌损伤的序列和指向性:一项观察性研究
Yixuan Wang1, Jianxiong Chen2,3, Lin Jin4
1Department of Medical Ultrasound, Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
Frontiers in cardiovascular medicine
|November 1, 2023
概括
COVID-19 感染会损害心脏功能,左心室全球纵向菌株 (LVGLS) 是疾病进展的关键指标. 在COVID-19患者中早期发现心脏变化对于管理潜在并发症至关重要.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 众所周知,COVID-19 (冠状病毒疾病2019) 影响多个器官系统,包括心血管系统.
- 患有COVID-19的患者可以出现心脏功能障碍,从轻度到重度的病例.
- 了解特定的心脏变化及其进展对于患者管理至关重要.
研究的目的:
- 为了比较轻度和中度至重度COVID-19患者之间的心脏功能指标.
- 为了确定COVID-19患者心肌损伤的序列和方向性.
- 为了确定轻度COVID-19进展到中度或重度疾病的独立风险因素.
主要方法:
- 从2022年12月到2023年1月,对实验室确认的SARS-CoV-2感染患者进行前性研究.
- 将患者分为轻度,中度和严重的COVID-19群体.
- 收集临床,实验室,胸前回声心脏图和斑点跟踪回声心脏图参数进行比较分析.
主要成果:
- 除左心室喷射率 (LVEF) 之外,心声学参数在轻度组相比中度或重度组较低 (P <0.05).
- 轻度和中度组的LVEF比严重组的LVEF更高 (P<0.05).
- 左心室全球纵向菌株 (LVGLS) 和E/e'被确定为从轻度到中度/严重的COVID-19进展的独立风险因素. 在ROC分析中,LVGLS显示了0.861的曲线下的最高面积 (AUC).
结论:
- COVID-19的进展到中度或严重的疾病与心脏缩和心脏缩功能受损有关.
- LVGLS是轻度COVID-19病例进展的重要独立风险因素.
- 纵向心肌张力变化可能会在COVID-19相关心脏病的环形变化之前发生.
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