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可激活刺激的纳米医学与癌症治疗学相遇

Haonan Li¹, Yue Feng¹, Qiang Luo¹

¹Department of Radiology, and Department of Geriatrics, Laboratory of Heart Valve Disease, Huaxi MR Research Center (HMRRC), Laboratory of Stem Cell Biology, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-Related Molecular Network, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, China.

|November 1, 2023

概括

可激活刺激的纳米医学通过响应瘤特异性特征或外部触发器提供了增强的癌症治疗学. 本综述详细介绍了可激活刺激的纳米医学的进展,以改善诊断和治疗.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

可激活刺激的纳米医学对晚期癌症治疗至关重要.
这些纳米药物对内部 (低pH,高氧化还原) 或外部 (光,超声) 刺激作出反应.
它们提供了改善的生物安全性和增强的诊断/治疗疗效.

研究的目的:

审查用于临床需求的可激活刺激的感知纳米药物的发展.
详细阐述响应刺激的自我组装,拆卸和功能激活策略.
详细的结构设计和最先进的技术进展.

主要方法:

关于可激活刺激的纳米医学的当前文献的综述.
对瘤特异性特征和外源刺激源的分析.
讨论用于成像指导治疗的多功能神经学纳米医学.

主要成果:

新的刺激来源和优雅的设计刺激可激活的纳米医学已经出现.
多功能治疗纳米医学越来越多地用于图像引导的抗瘤疗法.
可激活刺激的方法可以提高诊断和治疗结果.

结论:

可激活刺激的纳米医学对临床癌症治疗学具有重大前景.
对结构设计和临床翻译的进一步研究是有必要的.
未来的展望集中在为迫切的临床需求优化疗效和安全.

关键词:

内源性刺激是一种内源性刺激.癌症治疗神经元学外源刺激是外源刺激.纳米医药是一种纳米医药.刺激激活的激活方式

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