甲状腺激素敏感性和糖尿病发病:一个纵向交叉滞后队列
Cancan Cui1, He Sui1, Zhijia Wang1
1China-Japan Union Hospital of Jilin University, Jilin University, Jilin, China.
Frontiers in endocrinology
|November 1, 2023
概括
甲状腺激素的敏感性并不预测甲状腺不良个体的糖尿病发病. 然而,高禁食葡萄糖可能会在甲状腺激素敏感性发生变化之前发生,这表明在代谢健康方面存在潜在的联系.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
背景情况:
- 甲状腺激素敏感性是一种与代谢健康相关的新型因素.
- 以前的研究表明,甲状腺激素敏感性和糖尿病之间存在截面联系.
- 甲状腺激素敏感性和糖尿病发病之间的纵向关系尚不清楚.
研究的目的:
- 调查甲状腺激素敏感性受损与随后出现糖尿病之间的纵向关联.
- 探索基线甲状腺激素敏感性是否能预测甲状腺免疫群体未来糖尿病的发展.
主要方法:
- 从2008-2009年至2019年或糖尿病发病时,每年跟踪7283名甲状腺功能良好的参与者的队列.
- 用多个指数评估甲状腺激素敏感性,包括TFQI,PTFQI,TSHI,TT4RI和FT3/FT4比率.
- 考克斯的比例危险模型和交叉滞后面板分析被用来分析数据.
主要成果:
- 在基线甲状腺激素敏感度指数和患糖尿病的风险之间没有发现显著的关联.
- 对糖尿病发病的调整后危险比率,每单位增加的敏感度指数,在统计学上并不显著.
- 交叉滞后分析表明,高的禁食葡萄糖水平可能先于甲状腺激素敏感性受损.
结论:
- 甲状腺激素敏感性状态没有被确定为糖尿病发病的预测因子,在研究的甲状腺免疫群体中.
- 观察到高的禁食葡萄糖水平 (超过7.0 mmol/L) 先于甲状腺激素敏感性指数受损的发展.
- 这些发现表明,代谢失调,特别是高血糖,可能会影响甲状腺激素敏感性,而不是相反.
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