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相关概念视频

Protein Families02:47

Protein Families

15.4K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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相关实验视频

Updated: Jul 12, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

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MFPPDB:一个全面的多功能植物类数据库.

Yaozu Yang1,2,3, Hongwei Wu1, Yu Gao1

  • 1School of Information and Computer, Anhui Agricultural University, Hefei, China.

Frontiers in plant science
|November 1, 2023
PubMed
概括
此摘要是机器生成的。

一个新的数据库,MFPPDB,列出了超过140万种具有治疗功能的植物性. 该资源通过提供有效访问用于药物发现的多功能植物来加速研究.

关键词:
我们的数据库数据库数据库数据库.多功能的多功能.型体 (peptidomes) 是一种型体.植物植物植物植物植物.治疗性的治疗性.

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科学领域:

  • 生物化学和分子生物学
  • 药理学和药物发现
  • 生物信息学和计算生物学

背景情况:

  • 植物自然产生生物活性来防御.
  • 实验验证植物衍生的功能是资源密集型和耗时的.
  • 需要有效和准确的方法来预测植物的治疗功能.

研究的目的:

  • 开发具有预测治疗功能的植物的综合存储库.
  • 为了促进植物衍生的预测和开发,用于治疗应用.
  • 通过提供可搜索的数据库,加快植物体学研究.

主要方法:

  • 开发多功能植物基数据库 (MFPPDB).
  • 包括来自121种单一或多重预测功能的植物种的1,482,409种植物.
  • 类的分类为41种功能类型 (例如,抗菌,抗癌).
  • 整合物理化学性质和搜索功能 (按物种,ID,功能,同电点,分子量).
  • 与九个现有的精心策划的数据库交叉引用预测,以确定功能潜力.

主要成果:

  • MFPPDB含有1,482,409种植物原产的治疗性.
  • 类覆盖41个功能类别,包括抗微生物,抗病毒和抗癌活动.
  • 通过数据库匹配,至少确定了293,408种具有功能潜力的.
  • 一个用户友好的网页界面允许访问详细的信息.

结论:

  • MFPPDB是具有多种治疗功能的植物的宝贵综合资源.
  • 该数据库有助于在植物体学方面进行全面研究,并加速药物发现.
  • MFPPDB是免费访问的,促进植物衍生的更广泛的科学探索和应用.