对于SARS-CoV-2感染的急性后续症状的独特时间轨迹和风险因素
Chen Chen1, Sairam Parthasarathy2, Jacqueline M Leung1
1Verily Life Sciences, South San Francisco, CA, United States.
Frontiers in medicine
|November 1, 2023
概括
SARS-CoV-2感染 (PASC) 的后急性后续症状呈现出不同的轨迹,包括急性疾病后出现的新症状. 在急性感染期间使用全身皮质类固醇与发展PASC有关.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 临床医学 临床医学
背景情况:
- 对SARS-CoV-2感染 (PASC) 后急性后果的长度评估对于了解疾病至关重要.
- 研究急性疾病的症状演变有助于识别PASC轨迹.
研究的目的:
- 分析3个月的症状变化,以了解PASC.
- 为了确定与PASC发展相关的临床因素.
主要方法:
- 未来的队列研究设计.
- 对临床数据和症状学的集群和病例控制分析.
- 感染后3个月的症状评估.
主要成果:
- 确定了三个PASC表型:转移性,持久性和偶发性.
- 事件PASC表型显示出更多的症状和更高的患病率,尽管年龄较小,住院时间较低.
- 在急性感染期间系统性皮质类固醇的使用与3个月后的PASC相关 (OR:2.23).
结论:
- 确定了一种PASC事件表型,在急性疾病期间没有症状.
- 在急性感染PASC期间使用高剂量类固醇的关联表明潜在的预防目标.
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