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用于治疗IV酸盐依赖患者瘤诱导骨质疏松症的热废除

Evert F S van Velsen^1,2, Tychon E A Geeraedts³, Ariadne Bosman^1,2

¹Department of Internal Medicine, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.

JCEM case reports

|November 1, 2023

概括

瘤诱导骨质疏松症 (TIO) 是一种罕见的疾病,由瘤分泌纤维细胞生长因子23引起. 用CT指导的热性除 (TA) 为难以达到的瘤提供了不那么侵入性的替代手术,成功治疗了严重的病例.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
放射学放射学是一门学科.

背景情况:

瘤诱导性骨质疏松症 (TIO) 是一种罕见的副瘤综合征,其特征是纤维细胞生长因子23 (FGF23) 的过度分泌.
它导致严重的低血和骨矿化缺陷,往往需要密集治疗.
手术切除是治愈性的,但对于困难位置的瘤来说具有挑战性.

研究的目的:

评估CT导向热性除 (TA) 作为TIO的最小侵入性治疗的疗效.
在手术不理想的情况下,通过TA成功管理严重的TIO病例.

主要方法:

一名40岁的妇女患有严重的低血和高FGF23被诊断为TIO.
图像检测显示,胸椎Th7和Th8.8的疑似瘤.
由于瘤的位置,CT引导的TA在Th8进行,避免了广泛的脊椎切除.

主要成果:

在CT导向的TA之后,患者的低酸血症消失了.
静脉酸盐补充剂被停止,这表明治疗成功.
在手术后没有报告任何并发症.

结论:

CT引导的TA是一种可行的,有效的替代方案,可以替代TIO的广泛手术.
这种最少的侵入性方法可以在具有挑战性的解剖位置上成功管理TIO.
在传统手术带来重大风险的情况下,TA为TIO患者提供了一个有前途的治疗选择.

关键词:

低酸性骨质疏松症是什么微波除是微波除的一种方法.热性剥离是一种热性剥离.瘤诱导的骨质疏松症

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