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在三维微血管模型中,辐射会诱导急性和亚急性血管回归

Dong-Hee Choi^1,2, Dongwoo Oh³, Kyuhwan Na^1,2

¹School of Mechanical Engineering, Korea University, Seoul, Republic of Korea.

Frontiers in oncology

|November 1, 2023

概括

放射治疗会损害血管,导致结构和功能上的变化. 一个新的3D模型显示,辐射损害了血管的恢复和功能,为改善癌症治疗提供了洞察力.

科学领域:

在瘤学瘤学.
血管生物学血管生物学
辐射生物学辐射生物学

背景情况:

放射治疗是癌症治疗的基石,约有50%的患者使用.
副作用和瘤微环境限制了放射治疗的疗效.
血管在正常和瘤组织对辐射的反应中起着至关重要的作用.

研究的目的:

用3D微血管芯片模型研究辐射对血管的影响.
评估辐射诱导的血管细胞,结构和功能变化.
评估该模型在改善放射治疗方面的潜力.

主要方法:

使用3D微血管在芯片上的模型模仿生理血管.
通过DNA双链断裂 (DSB),细胞亡和细胞活力评估细胞损伤.
血管网络的量化结构变化 (面积,分支长度,直径) 和功能变化 (阻塞,透性).

主要成果:

辐射诱导了显著的细胞损伤,包括DSB和细胞亡,降低了细胞活力.
在成熟和发展中网络中观察到血管结构的减少和回归.
证明血管阻塞和透性增加,表明功能受损.
辐射抑制了血管恢复和血管生成潜力,导致逐渐恶化.

结论:

芯片上的3D微血管模型有效地代表了辐射诱导的血管功能障碍.
该模型可以评估辐射对血管的急性和慢性影响.
研究结果表明,通过了解血管反应,有可能提高放射治疗的效率.

关键词:

负面影响负面影响在芯片上的微血管.量化量化量化的量化.辐射治疗是一种治疗.辐射损伤的血管系统受损.

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