由于目前双价COVID-19疫苗的祖先升,造成了深刻的免疫印记
Qian Wang1, Yicheng Guo1, Anthony R Tam2
1Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Cell reports. Medicine
|November 1, 2023
概括
与单价疫苗相比,双价COVID-19疫苗不会改善对Omicron变异的抗体反应. 来自祖先尖的免疫印记可能会阻碍更广泛的保护,建议将其从未来的疫苗配方中删除.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 针对祖先和Omicron BA.5菌株的双相对应的COVID-19 mRNA疫苗已经在全球取代了单相对应的疫苗.
- 存在关于免疫印记和第四剂疫苗针对Omicron亚型的有限疗效的担忧.
研究的目的:
- 为了研究和比较不同的COVID-19疫苗接种和感染策略后的抗体反应.
- 评估双价比单价增强剂和Omicron突破性感染对中和抗体标位的影响.
主要方法:
- 对72名具有不同疫苗接种史 (单价初级系列,双价/单价增剂) 和突破性感染 (BA.5,BQ) 的参与者的抗体反应分析.
- 对各种SARS-CoV-2变种的结合和病毒中和抗体标位的测量.
- 抗原映射以了解抗体的宽度和特异性.
主要成果:
- 与单价增强剂相比,双价增强剂不会产生与单价增强剂相比,对Omicron亚变体的中和抗体标位明显更高.
- 在SARS-CoV-2 Omicron突破性感染中,Omicron亚变体的优异中和得到了结果.
- 抗原测绘表明,双价疫苗中的祖先尖端成分诱导了强大的免疫印记,限制了对Omicron BA.5成分的抗体反应.
结论:
- 双等效的COVID-19疫苗可能无法提供对Omicron变种的优越保护,这是由于祖先尖的免疫印记.
- 奥米克朗突破感染引起的中和抗体比目前的双价增强剂更广泛.
- 建议在未来的双价疫苗设计中省略祖先尖端组件,以加强对不断演变的SARS-CoV-2变种的保护.
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