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杏仁体谷氨酸受体对患有创伤后应激障碍的老鼠心血管功能的影响

Ya-Yang Wu^1,2, Kun-Yi Cai^1,2, Yu-Jie Wu^1,2

¹Psychophysiology Laboratory, Wannan Medical College, Wuhu 241002, China.

Sheng li xue bao : [Acta physiologica Sinica]

|November 1, 2023

概括

创伤后应激障碍 (PTSD) 与心血管问题有关. 这项研究发现,阻断杏仁体中的AMPA受体会增加PTSD老鼠的心率和神经活动,这表明它们在心血管调节中的作用.

科学领域:

神经科学是一个神经科学.
心血管研究研究心血管研究
精神病学是一个精神病学.

背景情况:

创伤后应激障碍 (PTSD) 与心血管疾病风险增加有关.
杏仁体在调节心血管功能方面发挥着至关重要的作用.
杏仁体中的谷氨酸受体 (GluR) 与PTSD相关的心血管变化有关.

研究的目的:

为了研究杏仁体谷氨酸受体 (GluRs) 在PTSD大鼠模型中的心血管活动中的作用.
探索AMPA受体在桃体 (CeA) 中央核中的特定参与调节PTSD心血管反应.

主要方法:

通过复合压力方法建立了PTSD的老鼠模型.
对PTSD的评估包括体重增加分析和高加迷宫测试.
杏仁体GluR表达的分析使用了西方的斑点.
在体内多通道同步记录技术被用于监测心血管和神经活动后微注射到CeA.

主要成果:

与对照组相比,PTSD老鼠的体重增加减少,手臂开放时间比率降低.
在PTSD大鼠的杏仁体中,AMPA受体含量明显较低.
将AMPA受体阻塞剂 (KYN,CNQX) 微注射到PTSD老鼠的CeA中,导致RVLM神经元发射频率和心率增加.

结论:

杏仁体中央核中的AMPA受体参与调节PTSD中心血管活动.
这些发现表明,杏仁体的AMPA受体可能通过PTSD的抑制途径调节心血管功能.
向杏仁体的AMPA受体可以为与PTSD相关的心血管并发症提供潜在的治疗策略.

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