8.2m/s的脉冲波速度作为与心血管目标器官损伤存在相关的值
Sayuri Inuzuka1, Priscila Valverde de Oliveria Vitorino2, Adriana Sebba Barroso1
1Universidade Federal de Goiás - Liga de Hipertensão Arterial, Goiânia, GO - Brasil.
Arquivos brasileiros de cardiologia
|November 1, 2023
概括
脉冲波速度 (PWV) 8.2 m/s对于早期检测高血压相关心血管损伤,包括左心室缩和心血管斑块,最为敏感.
科学领域:
- 心血管医学 心血管医学
- 高血压研究 高血压研究
- 诊断生物标志物 诊断生物标志物
背景情况:
- 对于脉冲波速度 (PWV) 存在既定的正常值和参考值.
- 与心血管生物标志物最强烈相关的特定PWV值尚不清楚.
研究的目的:
- 为了确定PWV值最能预测高血压患者的目标器官损伤 (TOD).
- 为了将PWV与左心室缩 (LVH),内心介质厚度 (IMT) 增加和大脑动脉斑块相关联.
主要方法:
- 在119名高血压患者的横截面研究.
- 接收器运行特征 (ROC) 曲线分析以评估生物标志物相关性.
- 统计学意义设置为p < 0.05.05.
主要成果:
- ROC分析显示PWV值为8.1m/s (LVH),8.2m/s (IMT) 和8.7m/s (状斑块).
- 8.2m/s的PWV最好地确定了所有三个TOD生物标志物.
- PWV>8.2 m/s与LVH (p<0.001) 有显著的相关性,带斑块 (p=0.003) 和增加的IMT (p=0.004).
结论:
- 8.2m/s的PWV显示了对高血压中心血管TOD早期检测的高灵敏度.
- 这一PWV值是识别高风险患者的关键指标.
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