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在体外和在体内研究功能化的聚氨表面,以了解生物学相关的相互作用

Paulina Chytrosz-Wrobel¹, Monika Golda-Cepa¹, Kamil Drozdz²

¹Faculty of Chemistry, Jagiellonian University in Krakow, Gronostajowa 2, 30-387 Krakow, Poland.

ACS biomaterials science & engineering

|November 1, 2023

概括

氧气等离子处理修改了聚氨表面,增强了呼吸道应用的生物材料与宿主相互作用. 这项研究详细介绍了表面变化及其对细胞和细菌粘附的影响.

科学领域:

生物材料科学生物材料科学
表面化学表面化学
聚合物科学聚合物科学

背景情况:

生物材料-水性接口对于植入物-宿主相互作用至关重要.
了解这种接口对于开发有效的生物材料至关重要.
聚氨是一种常见的生物材料,但其表面性能需要针对特定应用进行优化.

研究的目的:

研究氧气等离子处理对用于呼吸道应用的聚氨表面的影响.
描述由血功能化诱导的物理化学和生物变化.
用分子动力学模拟来阐明聚氨-水接口的纳米级行为.

主要方法:

氧气等离子处理聚氨表面.
使用原子力显微镜,FTIR,DTA,XPS,SIMS和接触角测量进行表面表征.
用A549细胞,金黄色葡萄球菌和Pseudomonas aeruginosa进行生物评估.
模拟未经修改和具有等离子体功能的聚氨-水接口的分子动力学模拟.

主要成果:

等离子处理显著改变了聚氨表面的物理化学特性.
表面功能化导致含氧组的增加,链末端的替代率为20%.
实验表面的自由能量与模拟衍生的值有很好的相关性.
生物测试表明,有可能改善植入物与宿主相互作用.

结论:

氧气等离子功能化是一种有效的方法来修改用于生物医学应用的聚氨表面.
该研究提供了详细的纳米尺度了解等离子处理的聚氨-水接口.
这些发现支持在呼吸系统接触应用中使用功能化聚氨.

关键词:

细菌的粘附细菌的粘附生物相容性生物相容性分子动力学分子动力学氧气等离子体氧气等离子体聚氨是一种聚氨.

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