骨肌肉和肝脏特异性BBSome缺陷的代谢后果
Younes Rouabhi1, Deng-Fu Guo1,2, Yuying Zhao1
1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa, United States.
American journal of physiology. Endocrinology and metabolism
|November 1, 2023
概括
BBSome蛋白质复合体对于代谢调节至关重要. 肝脏BBSome通过支持胰岛素信号和能量生产来维持体重和血糖.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 蛋白质复合体的功能 蛋白质复合体的功能
- 肥胖和糖尿病的研究研究.
背景情况:
- 巴德特-比德尔综合征 (BBS) 蛋白质复合体 (BBSome) 对新陈代谢调节至关重要,因为它缺少会导致肥胖和2型糖尿病.
- 在胰岛素敏感组织 (如骨肌肉和肝脏) 中,BBSome的具体作用尚不清楚.
研究的目的:
- 调查BBSome对骨肌肉和肝脏代谢调节的贡献.
- 阐明BBSome缺乏影响葡萄糖平衡和胰岛素敏感性的机制.
主要方法:
- 在小鼠中,骨肌特异性和肝细胞特异性Bbs1基因删除.
- 评估体重,处理葡萄糖和胰岛素敏感性.
- 在各种组织中分析胰岛素受体信号传递和线粒体功能.
主要成果:
- 骨肌肉Bbs1的删除没有影响体重或葡萄糖,但在雌性小鼠和接受肥胖饮食的雄性小鼠中改善了胰岛素敏感性.
- 在正常食小鼠中,肝细胞Bbs1被删除导致体重增加,葡萄糖处理受损,胰岛素敏感性降低.
- 肝脏BBSome的损失导致线粒体功能障碍,血胰岛素受体水平降低,肝脏胰岛素信号减弱.
结论:
- 肝脏BBSome,而不是肌细胞BBSome,在能量稳态和胰岛素敏感性中起着至关重要的作用.
- 肝脏BBSome对于胰岛素受体贩运和适当的胰岛素信号传递至关重要,影响整体代谢控制.
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