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评估通过放宽自戒烟以来的最大几年门来提高肺部查资格的影响:一个模拟建模研究

Rafael Meza^1,2,3, Pianpian Cao², Koen de Nijs⁴

¹Department of Integrative Oncology, British Columbia Cancer Research Institute, Vancouver, British Columbia, Canada.

|November 1, 2023

概括

扩大肺癌查范围,包括戒烟时间较长的前吸烟者 (YSQ),可以增加诸如避免死亡之类的好处. 通过专注于具有充足预期寿命的个体,可以保持这些益处,同时减少危害.

科学领域:

肺部病理学肺部病理学
在瘤学瘤学.
预防医学预防医学

背景情况:

目前的美国肺癌查指南针对的前吸烟者是戒烟15年以下 (YSQ).
新出现的证据表明,选具有较长YSQ的前吸烟者有潜在的好处.

研究的目的:

评估肺癌查的益处和危害,使用不同的YSQ值和戒烟年龄.
评估预期寿命对查结果的影响.

主要方法:

利用两个经过验证的肺癌模型来模拟查场景.
分析了包括查,避免死亡,增加寿命,错误阳性和过度诊断在内的结果.
根据预期寿命进行了敏感性分析.

主要成果:

放松YSQ标准增加了查的好处和危害.
提高查终止年龄带来了更多的好处,但也增加了过度诊断.
将查限制在具有≥5年预期寿命的个体上,维持了益处,同时减少了危害.

结论:

扩大肺癌查范围,包括15YSQ以上的前吸烟者,可以显著增加避免死亡和增加寿命.
通过优先考虑具有足够预期寿命的个体,可以减轻额外的伤害.

关键词:

早期发现癌症的早期检测肺部瘤是什么肺部瘤查检查查检查查检查查检查吸烟是为了吸烟.

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