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外节延伸和上皮细胞粘附分子在口腔状细胞癌中的过度表达
Hiromasa Fukushima1, Tomofumi Naruse2, Kohei Furukawa2
1Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan kobeliketaisyou@yahoo.co.jp.
Anticancer research
|November 1, 2023
概括
同时的化疗放射治疗 (CCRT) 改善了口腔癌患者的主要外节延伸 (ENEma) 的存活率. 然而,CCRT对轻微的突节外延伸 (ENEmi) 病例没有任何好处,特别是那些对上皮细胞粘附分子 (EpCAM) 负的病例.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 癌症研究 癌症研究
背景情况:
- 口腔状细胞癌 (OSCC) 患者与外节延伸 (ENE) 往往接受基斯普拉丁基化疗放射治疗 (CCRT) 后部剖析.
- 关于ENE严重程度和EpCAM表达对OSCC中CCRT疗效的影响尚不清楚.
研究的目的:
- 要评估CCRT在OSCC中的有效性是否与ENE程度 (小与大) 有所不同.
- 确定在接受CCRT的OSCC患者中EpCAM表达和预后之间的关联.
主要方法:
- 在部剖析后对170名经过病理确认的部转移 (pN+) 的OSCC患者进行了回顾性分析.
- ENE的分类为小 (ENEmi; <2毫米) 和大 (ENEma; ≥2毫米).
- 在瘤组织中对EpCAM表达的免疫组合化学评估.
主要成果:
- 先进的T阶段和ENEma是预后不佳的重要预测因素.
- 五年生存率为73.7% (ENE-),75.5% (ENEmi) 和28.0% (ENEma) 的情况.
- 在ENEma病例中,CCRT改善了生存率,但在ENEmi病例中没有改善. 在ENEma中,EpCAM阳性与更差的预后相关.
结论:
- 手术后的CCRT可能有利于OSCC患者与ENEma.
- EpCAM表达是ENEma中潜在的负预后因素.
- 在ENEmi/EpCAM阴性OSCC患者中,CCRT可能会被遗漏,而不会影响生存.
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