炎症和营养指数作为胃癌老年患者的预后标记
Ryota Otsuka1, Hideki Hayashi2, Masaya Uesato2
1Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan ryotaotsuka@yahoo.co.jp.
Anticancer research
|November 1, 2023
概括
预后和营养指数 (PNI) 是接受胃癌手术的老年患者生存的有价值预测指标. 低PNI表明预后更差,使其成为这个年龄组整体和无复发生存的独立因素.
科学领域:
- 在瘤学瘤学.
- 老年医学 老年医学
- 手术瘤学手术瘤学
背景情况:
- 炎症和营养标志物已成为癌症的预后指标.
- 这些标记在八十岁的胃癌患者的预后价值仍在调查中.
- 人口老龄化需要了解老年手术患者的预后因素.
研究的目的:
- 评估胃癌老年患者 (≥80岁) 术前外周血液炎症和营养指数的预后意义.
- 确定像中性粒细胞-淋巴细胞比率 (NLR),血小板-淋巴细胞比率 (PLR),淋巴细胞-单细胞比率 (LMR) 和预后和营养指数 (PNI) 这样的指数是否预测胃切除术后的生存率.
主要方法:
- 对103名年龄≥80岁,经过激进胃切除术的患者进行了回顾性分析.
- 在手术前的NLR,PLR,LMR和PNI的评估.
- 使用卡普兰-梅尔和考克斯回归模型分析的生存结果.
主要成果:
- NLR,PLR和LMR没有显示与整体存活率 (OS) 或无复发存活率 (RFS) 的显著关联.
- 预后和营养指数 (PNI) 较低的患者表现出明显更差的3年OS (63.9% vs. 81.2%) 和RFS (55.3% vs. 77.6%).
- 多变量分析确定了低PNI作为这个队列中OS和RFS的独立预测因子.
结论:
- 手术前的预后和营养指数 (PNI) 是一个重要的独立预后因素,对于经过激进手术的老年胃癌患者的生存.
- 其他炎症标志物如NLR,PLR和LMR在这个特定的老年人群中没有被发现是独立的预测因素.
- 在八十岁的胃癌患者中,PNI可以帮助风险分层和治疗规划.
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