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在儿科患者中对大脑[F]FDG-PET吸收的半定量分析
Álvaro Cruz-Cortes1, Arturo Avendaño-Estrada2, Sarael Alcauter3
1Unidad de Radiofarmacia-Ciclotrón, División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico.
Pediatric radiology
|November 1, 2023
概括
儿童的脑糖代谢,用氧糖-正子辐射断层扫描 (FDG-PET) 测量,随着年龄和性别的变化. 摄入量增加到青春期,观察到区域和性别差异.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 儿科代谢 儿科代谢
背景情况:
- 儿童患者使用[18F]氧葡萄糖-正子发射断层扫描 (FDG-PET) 的脑糖类代谢尚未完全理解.
- 描述正常的大脑FDG吸收对于解释潜在的疾病相关变化至关重要.
研究的目的:
- 描述 [18F]FDG-PET大脑吸收在没有中枢神经系统疾病的儿科患者的大队伍中.
- 建立不同儿科年龄组大脑FDG吸收的规范性数据.
主要方法:
- 795 [18F]FDG-PET扫描18岁以下没有中枢神经系统疾病的儿童的分析.
- 脑图像的空间规范化和标准化吸收值 (SUV) 的计算.
- 探索SUV作为年龄,性别和大脑区域的函数.
主要成果:
- 在叶观察到的最高[18F]FDG吸收,在顶叶和脑干观察到的最低.
- 大脑FDG吸收量随年龄增加,直到12岁,从13-17岁没有显著变化.
- 在青春期观察到整个大脑吸收的性别差异,在婴儿时期发现时间和中心区域的半球不对称性.
结论:
- 儿童大脑的糖分代谢,通过[18F]FDG-PET SUV平均值进行评估,成熟到青春期早期 (13岁以下),区域差异较大.
- 年龄,性别和大脑区域显著影响[18F]FDG吸收.
- 在婴儿中,时间和中心区域存在显著的半球不对称性.
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