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[案例报告:Pfizer-BioNTech COVID-19 mRNA 疫苗接种后的MPO-ANCA相关血管炎]

Fabio Mazza¹, Angela Cicciarelli¹, Filomena Rubino¹

¹UO Nefrologia e Dialisi SS Trinità Sora, Italia.

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia

|November 1, 2023

概括

一名71岁的男子在接种了第三剂COVID-19疫苗后出现了髓氧化酶-抗中性粒细胞质抗体 (MPO-ANCA) 血管炎. 治疗部分改善了他的功能和症状.

科学领域:

免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學專業.
疫苗学疫苗学疫苗学

背景情况:

抗中性粒细胞质抗体 (ANCA) 相关的血管炎 (AAV) 是一种罕见的自身免疫性疾病.
针对COVID-19的mRNA疫苗与各种与免疫相关的不良事件有关.
肺综合征是AAV的严重表现.

研究的目的:

在mRNA COVID-19疫苗接种后报告MPO-ANCA相关的血管炎病例,呈现为肺综合征.
描述这个患者的诊断结果和治疗结果.

主要方法:

一个71岁的男性的病例报告.
诊断工作包括脏活检.
治疗包括透析,rituximab和类固醇脉冲疗法.

主要成果:

患者患有MPO-ANCA血管炎,并接种了mRNA后增强疫苗.
脏活检证实了乳腺免疫新月状质隆炎.
随着治疗,观察到功能和宪法症状的部分改善.

结论:

mRNA COVID-19 疫苗接种可能是易受感染的个体中AAV的潜在触发因素.
早期诊断和多模式治疗对于治疗肺综合征的AAV至关重要.
在接下来的COVID-19疫苗剂量或感染后,没有发现疾病复发.

关键词:

在 ANCA 血管炎.这就是SARS-CoV-2病毒.提升剂量是提升剂量的.细胞因子风暴是什么意思这是mRNA疫苗.

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