用长效注射抗精神病药物出院的精神分裂谱系疾病的法医患者的治疗坚持:一项比较的3年镜像研究
Yasin Hasan Balcioglu1, Sinem Ozdemir, Fatih Oncu
1Forensic Psychiatry Unit, Department of Psychiatry, Bakirkoy Prof Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery, Istanbul, Turkey.
International clinical psychopharmacology
|November 1, 2023
概括
与口服抗精神病药物相比,使用长效注射抗精神病药物 (LAI) 治疗精神分裂症谱系障碍 (SSD) 的患者的出院改善了药物坚持. 这导致在法医精神病学机构的住院和定罪减少.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 法医精神病学 法医精神病学
背景情况:
- 精神分裂症谱系障碍 (SSD) 在法医精神病学环境中构成重大挑战.
- 保持抗精神病药物的坚持对于管理SSD和预防复发至关重要.
- 长效注射抗精神病药 (LAI) 是每日口服药物的替代品.
研究的目的:
- 为了比较长效注射抗精神病药物 (LAI) 与仅口服的抗精神病药物在改善药物坚持和临床结果方面的有效性.
- 评估从法医精神病学单位出院的SSD患者的中长期改善情况.
主要方法:
- 这是一项81名SSD患者的3年后期镜像研究.
- 患者在出院后被分为口服单独和口服+LAI组.
- 使用"覆盖日数比例"方法测量了抗精神病药物的坚持.
- 包括住院和定罪在内的临床结果在出院前和出院后的时间之间进行了比较.
主要成果:
- 这两组患者在出院后的住院,定罪和住院数月均显著减少,相比于出院前的情况.
- 口服+LAI组在后索引期表现出更明显的治疗坚持度的改善.
- 两组之间没有观察到临床结果改善的显著差异.
结论:
- 在SSD的法医精神科队列中,与LAI的出院与抗精神病药物坚持的中长期改善有关.
- 在这种人群中,使用LAI可能是一个有价值的策略,以提高治疗坚持和临床稳定性.
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