在患有海湾战争疾病的退伍军人的外周血液单核细胞中,生物能功能下降
Joel N Meyer1, William K Pan1, Ian T Ryde1
1Nicholas School of the Environment, Duke University, Durham, NC, United States of America.
PloS one
|November 1, 2023
概括
海湾战争疾病 (GWI) 与退伍军人的线粒体功能和能量生产下降有关. 这项研究在GWI患者中发现了较低的呼吸道和糖解活性,这表明细胞能量生成受损.
科学领域:
- 线粒体生物学 线粒体生物学
- 退伍军人健康 退伍军人的健康
- 环境医学 环境医学
背景情况:
- 海湾战争疾病 (GWI) 影响了许多退伍军人,原因不明.
- 线粒体功能障碍是潜在的贡献者,症状重叠和污染物影响表明.
- 以前缺乏对GWI退伍军人线粒体呼吸的直接评估.
研究的目的:
- 调查与没有GWI的海湾战争退伍军人的线粒体功能和完整性.
- 评估线粒体呼吸,DNA完整性和能量代谢的测量.
- 探索GWI,环境暴露和线粒体参数之间的关联.
主要方法:
- 在114名海湾战争退伍军人 (80名有GWI,34名没有) 的病例控制研究中.
- 分析线粒体呼吸,细胞外酸化,mtDNA拷贝数和白细胞中的DNA损伤.
- 收集有关暴露 (杀虫剂,胺,化学/生物制剂) 和健康指标的调查数据.
主要成果:
- 患有GWI的退伍军人显示mtDNA含量增加,但DNA损伤没有差异.
- 在GWI退伍军人中显著降低基底和ATP相关的氧气消耗 (呼吸功能).
- 在GWI退伍军人中观察到减少的细胞外酸化 (糖解活性).
- 在GWI和被召回的农药,胺和战争药物的暴露之间发现了强烈的关联.
结论:
- 线粒体呼吸功能的降低和糖解活性表明GWI老兵的能量可用性降低.
- 线粒体功能障碍是导致海湾战争疾病的一个重要因素.
- 环境暴露可能在GWI通过线粒体通路的发展中发挥关键作用.
相关概念视频
01:15Myasthenia Gravis: Diagnostic Tests
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
01:24Muscle Recovery and Fatigue
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:22Myasthenia Gravis ll: Pathophysiology
The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...