在非便秘性刺激性肠综合征中便短链脂肪酸:基于catabotyping分析的潜在临床相关分层因素
Giorgio Gargari1, Giacomo Mantegazza1, Valentina Taverniti1
1Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Gut microbes
|November 1, 2023
概括
与健康个体相比,肠道微生物组在非便秘的刺激性肠综合征 (IBS) 患者中不同. 特定的短链脂肪酸 (SCFA) 水平定义了不同的IBS亚组,建议个性化治疗方法.
科学领域:
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 肠道微生物群及其代谢物,如短链脂肪酸 (SCFA),与刺激性肠道综合征 (IBS) 病原发生有关.
- 在IBS病理生理学中SCFA的确切作用尚不清楚,需要进一步调查.
研究的目的:
- 调查非便秘IBS患者 (NC-IBS) 和健康对照人群 (HC) 之间的便微生物组结构和SCFA水平的差异.
- 根据SCFA概况及其相关的细菌特征,在NC-IBS中识别不同的子组.
主要方法:
- 16S rRNA基因分析用于分析细菌社区结构.
- 超高性能液体染色学与并联质谱学 (UPLC-MS/MS) 量化了便中的SCFA水平.
- 从19家意大利医院的100名HC和240名NC-IBS患者收集了便样本.
主要成果:
- 与HC受试者相比,在NC-IBS患者的便微生物组中观察到显著的差异.
- 健康的对照组在样本内显示出更高的微生物生物多样性.
- 对NC-IBS患者进行分类,分为两个不同的便catabotype子组 ("高"和"低"SCFA水平),每个都有独特的细菌特征.
结论:
- 便SCFA概况,特别是较高的SCFA水平,可能表明IBS有明显的临床表型.
- 这些发现突出了肠道微生物群,SCFA和IBS症状之间的复杂相互作用.
- 针对肠道微生物组及其代谢物的个性化管理策略对于IBS治疗至关重要.
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