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Updated: Jul 12, 2025

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在表达乙型肝炎病毒表面抗原的CRISPR/Cas9工程细胞系中,REP 2139的泛基因抗病毒作用

Léna Angelo1, Andrew Vaillant2, Matthieu Blanchet1,2

  • 1Institut National de la Recherche Scientifique-Centre Armand-Frappier Santé Biotechnologies, Laval, Canada.

PloS one
|November 1, 2023
PubMed
概括

核酸聚合物 (NAP) 有效抑制乙型肝炎病毒 (HBV) 表面抗原 (HBsAg) 在所有测试的基因型中释放,包括疫苗逃生突变物. 这表明NAP可能提供了一种泛基因学方法,以实现慢性HBV感染的功能治疗.

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