移植患者的病毒特异性T细胞疗法 - 一个单一中心的经验
Manish Anand1, Jake Nysather1, Gregory McGraw1
1Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
概括
针对病毒的特异性T细胞疗法 (VSTs) 在移植接受者中显示出治疗腺病毒,BK病毒和细胞巨乳病毒感染的前景. 虽然对腺病毒有效,但对其他病毒感染和长期安全性需要进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 移植 移植 移植 移植
- 病毒学 病毒学
背景情况:
- 接受脏移植的人面临着由腺病毒 (ADV),BK病毒 (BKV) 和细胞巨乳病毒 (CMV) 感染引起的重大风险,这会影响长期的结果.
- 目前的抗病毒疗法和查方法在治疗这些移植后病毒感染方面存在局限性.
研究的目的:
- 评估病毒特异性T细胞疗法 (VSTs) 在患有ADV,BKV和CMV感染的移植接受者的疗效和安全性.
- 描述移植中心与第三方VST用于管理耐火病毒感染的经验.
主要方法:
- 在2021年6月至2022年12月期间,对接受过VST治疗的ADV,BKV或CMV感染的移植患者进行了回顾性,单中心的审查.
- 关于免疫抑制,感染细节和患者结果的数据从电子医疗记录中收集.
主要成果:
- 在两名患者进行一次VST输液后,观察到腺病毒感染完全消失.
- BK病毒和细胞巨乳病毒感染显示出中度反应,在VST后的中位病毒载量大约减少了50%.
- 在23名患者中,有2名患者出现了慢性异种移植脏病和急性排斥,其中一个病例与膜增殖性球膜炎有关.
结论:
- 针对病毒的特异性T细胞疗法可能有利于患有抗病毒抗性或恶化的病毒感染的移植患者.
- 进一步的临床研究是必不可少的,以确认疗效,并评估与VSTs相关的短期和长期风险在这个患者群体.
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