严重的急性营养不良会通过循环的先天性免疫细胞促进细菌结合而不是促炎性细胞因子分泌
Tracy N Phiri1, Kuda Mutasa2, Sandra Rukobo2
1Tropical Gastroenterology and Nutrition group (TROPGAN), University of Zambia School of Medicine, Lusaka, Zambia.
Science advances
|November 1, 2023
概括
患有严重急性营养不良 (SAM) 的儿童表现出免疫细胞反应的改变,细菌结合增加,但炎症反应减少. 这种免疫转移可能会导致持续的疾病和退院后的较差结果.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 严重急性营养不良 (SAM) 与儿童感染传染病风险增加有关.
- 在患有SAM的儿童中,疑似存在免疫系统缺陷,导致高死亡率.
- 了解SAM中的先天性免疫细胞功能对于改善儿童健康结果至关重要.
研究的目的:
- 与健康对照组相比,研究SAM儿童循环天生的免疫细胞的功能差异.
- 探索免疫细胞功能与SAM的临床特征之间的关联.
- 为了确定免疫细胞功能是否预测持续的SAM和随后的健康风险.
主要方法:
- 医院住院SAM儿童 (n=141) 与健康对照组 (n=92) 的本质免疫细胞 (中性粒细胞,单细胞) 对细菌刺激的反应进行比较.
- 评估了细菌结合能力,单细胞激活和媒介分泌 (例如,细胞因子,髓氧化酶).
- 与消耗严重程度,艾滋病毒状况,年龄和持久性SAM相关的免疫功能.
主要成果:
- 在SAM患者中,中性粒细胞和单细胞结合ESCHERICHA大肠杆菌的增强.
- 在SAM儿童中,单细胞激活和促炎性细胞因子分泌量减少.
- 浪费严重程度,艾滋病毒感染和年轻的年龄与SAM的免疫反应改变有关.
- 在SAM住院患者中增加细菌结合和减少单细胞激活预测出院时持续的SAM.
结论:
- 严重的急性营养不良从根本上改变了先天性免疫细胞的功能,有利于细菌制而不是强大的炎症反应.
- 这种免疫失调可能解释SAM儿童感染易感性增加和退院后健康状况较差.
- 针对这些免疫缺陷可能是改善SAM儿童治疗结果的策略.
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