大麻素作为急性牙痛的替代止痛药
V Chrepa1,2, S Villasenor3, A Mauney3
1UTHealth San Antonio, School of Dentistry, San Antonio, TX, USA.
Journal of dental research
|November 1, 2023
概括
大麻二醇 (CBD) 有效降低了急性牙痛,提供了一个新的非阿片类药物止痛药选择. 这项研究表明,CBD显著改善了牙痛患者的疼痛评分和咬伤力.
科学领域:
- 牙科 牙科是指牙科的专业.
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 牙产生的疼痛在有限的非阿片类药物止痛药选项中具有重大临床挑战.
- 急性牙痛需要有效和安全的疼痛管理策略.
研究的目的:
- 评估口服大麻素 (CBD) 作为应急急性牙痛止痛药的疗效和安全性.
- 为了比较两种不同的CBD剂量 (10mg/kg和20mg/kg) 与安慰剂的影响.
主要方法:
- 一个随机的,安慰剂控制的临床试验,涉及61名中度至重度牙痛的患者.
- 单次口服剂量CBD (10 mg/kg或20 mg/kg) 或安慰剂,并进行3小时的监测.
- 使用视觉模拟尺度 (VAS) 评估疼痛,并评估二次结果,包括咬伤力,疼痛缓解的开始和持续时间以及不良事件.
主要成果:
- 与安慰剂相比,两组CBD都显示出显著的VAS疼痛减轻 (P<0.05).
- 获得CBD20mg/kg组的疼痛缓解比获得CBD10mg/kg组 (30分钟) 的疼痛缓解更快 (15分钟).
- 在CBD组中观察到咬伤力显著增加,常见的不良事件包括镇静,腹和腹痛.
结论:
- 口服大麻 (CBD) 是一种有效和安全的止痛药,用于治疗急性牙痛.
- CBD 提供了一个有前途的非阿片类药物替代品,用于治疗牙痛.
- 进一步的研究可能会探索CBD对牙痛的最佳剂量和长期影响.
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