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Updated: Jul 12, 2025

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
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α-Conotoxins的计算设计以准特定的尼古丁乙胆受体亚型

Xiaosa Wu1,2, Arik J Hone3,4, Yen-Hua Huang1

  • 1Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, 4072, Australia.

Chemistry (Weinheim an der Bergstrasse, Germany)
|November 1, 2023
PubMed
概括

海洋牛毒素通过阻断尼古丁性乙胆受体 (nAChRs) 提供神经疾病治疗的潜力. 一种新的计算方法加速了用于药物开发的选择性nAChR阻断共毒素的设计.

关键词:
药物设计 药物设计能量的计算 能量的计算分子建模分子建模nAChRR 是一个这是一种α-conotoxin.

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