系统性自身免疫性风湿性疾病患者中重复COVID-19感染的风险因素和结果:一个病例控制研究
Emily N Kowalski1, Xiaosong Wang1, Naomi J Patel2
1Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, 60 Fenwood Road, Boston, MA, 02115, USA.
Seminars in arthritis and rheumatism
|November 1, 2023
概括
年龄较小,rituximab和甲状腺素使用增加了系统性自身免疫性类风湿性疾病 (SARD) 患者重复COVID-19感染的风险. 重复感染通常是轻微的,住院时间很少,没有死亡.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 系统性自身免疫性类风湿性疾病 (SARDs) 可以影响免疫功能,可能增加对感染的易感性.
- 在SARD患者中理解重复COVID-19感染的风险因素对于临床管理和公共卫生策略至关重要.
研究的目的:
- 在SARD患者中识别与重复COVID-19感染相关的风险因素.
- 为了评估在这个患者群体中重复COVID-19感染的结果和严重程度.
主要方法:
- 在Mass General Brigham医疗保健系统中进行了一项病例控制研究.
- 确诊了患有SARD和确诊的COVID-19的患者,病例有重复感染和对照有单次感染.
- 使用条件后勤回归来分析患者特征与重复感染之间的关联.
主要成果:
- 年龄较小,rituximab使用和甲状腺素使用与重复COVID-19感染的风险增加显著相关.
- 与对照组相比,患有重复感染的患者年轻,患高血压或之前住院治疗COVID-19的可能性较低.
- 在患有重复感染的患者中,住院发生在6.6%的患者中,没有报告死亡.
结论:
- 年轻的年龄和特定的免疫抑制疗法 (利图西马布,甲铁酸) 是SARD患者重复COVID-19感染的关键风险因素.
- 在这个队列中,重复的COVID-19感染与一般温和的结果有关,其特点是住院和死亡率低.
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