简单疹病毒2血清学与社区居住的老年人中较薄的全脑皮质有关
Jackson A Roberts1, Mitchell S V Elkind2, Minghua Liu1
1Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, United States of America.
Journal of the neurological sciences
|November 1, 2023
概括
以前的感染,比如简单疹病毒2,可能会加速大脑衰老. 这项研究将特定的感染与减少的大脑结构联系在一起,可能会增加神经退行性疾病的风险.
科学领域:
- 神经科学是一个神经科学.
- 传染病流行病学 传染病流行病学
- 神经成像是一种神经成像.
背景情况:
- 以前的研究将常见的感染与认知能力下降联系起来.
- 北曼哈顿研究 (NOMAS) 调查了认知衰老及其危险因素.
研究的目的:
- 为了检查常见的传染病原体和神经成像大脑衰老标志物之间的横截面关联.
- 在NOMAS参与者中,研究细胞巨型病毒,简单疹病毒 (HSV-1,HSV-2),肺炎炎炎,杆菌和大脑结构之间的关系.
主要方法:
- 对455名NOMAS参与者的横截面研究.
- 评估了之前感染的血清学证据.
- 使用磁共振成像 (MRI) 检测全脑皮质厚度,阿尔茨海默病 (AD) 标志和海马体积.
- 进行了调整混因子的回归分析,检查连续血清学,血清阳性和传染性负担指数 (IBI).
主要成果:
- 较高的单纯疹病毒2 (HSV-2) 标位与大脑皮层厚度降低相关.
- 对HSV-2和Chlamydia pneumoniae的综合评分显示,对皮层厚度的降低具有添加效应.
- 对于细胞巨乳病毒或Helicobacter pylori,与神经成像结果没有发现显著的关联.
结论:
- 对HSV-2的阳性可能有助于加速大脑衰老.
- 对HSV-2和C. pneumoniae的联合暴露可能会加剧大脑结构的变化.
- 研究结果表明,像HSV-2这样的传染病原体可能会增加对认知障碍和神经退行症的脆弱性.
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