天生的免疫力:超越T细胞的辐射和免疫疗法组合
R A McMahon1, C D'Souza2, P J Neeson2
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Victoria, Australia.
放射治疗可以通过触发抗瘤免疫来增强免疫疗法,但也通过调节细胞抑制它. 了解辐射辐射的理解
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 辐射疗法 辐射疗法
背景情况:
- 放射治疗是癌症治疗的基石,已知可以调节免疫系统.
- 临床前数据表明,辐射和检查点免疫疗法之间有协同作用,通过免疫细胞的招募和激活来调解.
- 然而,结合辐射和免疫治疗的临床试验产生了令人失望的结果,需要更深入地了解它们的相互作用.
结论:
- 放射治疗对免疫系统具有复杂的,往往相反的作用,具有免疫刺激和免疫抑制的特性.
- 优化放射性免疫疗法需要全面了解辐射如何影响先天免疫细胞及其抑制功能.
- 对这些相互作用的进一步研究对于提高联合治疗策略的疗效至关重要.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
05:39Author Spotlight: Radiotherapy and Clonogenic Assays for Advancing Cancer Research and Personalized Medicine
Published on: April 5, 2024
相关概念视频
Tumor Immunotherapy
Cell-mediated Immune Responses
Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
