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在多发性硬化症中坚持疾病修饰药物的影响:对意大利现实世界数据的研究

Laura Maria Beatrice Belotti¹, Mirko Di Martino², Corrado Zenesini¹

¹Epidemiology and Statistics Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Via Altura 3, Bologna 40139, Italy.

Multiple sclerosis and related disorders

|November 1, 2023

概括

在多发性硬化症 (MS) 中对疾病修饰药物 (DMD) 的高度坚持显著降低了中度至严重复发的风险. 患者和医生的合作是确保治疗坚持以获得更好的结果的关键.

科学领域:

神经学神经学
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病.
改变疾病的药物 (DMD) 对于管理MS至关重要,旨在减少复发和残疾.
有限的现实世界数据存在于DMD坚持对复发率的影响.

研究的目的:

评估坚持疾病修饰药物 (DMDs) 对意大利多发性硬化症 (MS) 患者复发率的现实影响.
评估在五年内坚持水平与中度或重度复发的发生之间的关联.

主要方法:

一项基于人口的队列研究,利用意大利埃米利亚-罗马尼亚地区的行政数据库.
纳入标准:患有多发性硬化症 (PwMS) 的18岁以上的人,在2015-2019年期间开始他们的第一个DMD.
统计分析使用了考克斯回归模型,使用时间变化的暴露来评估坚持和复发相关性.

主要成果:

分析了2528名PwMS (平均年龄42岁,66%为女性) 的队列.
高度坚持PwMS的人与不坚持PwMS的人相比,中度或重度复发的风险降低了25% (HR 0.75,95% CI 0.58-0.98).
在多个灵敏度分析中,结果是稳定的.

结论:

在MS中对DMD的高度坚持与中度至重度复发的风险降低显著相关.
医生与患者在选择多发性硬化症和促进患者遵守治疗方面的合作对于有效的多发性硬化症管理至关重要.
这些发现强调了在现实世界MS护理中坚持的重要性.

关键词:

坚持的坚持坚持的坚持算法算法是一种算法.疾病修饰药物疾病修饰药物医疗保健管理数据库多发性硬化症是多发性硬化症.药学流行病学药学流行病学现实世界的数据数据.复发复发复发的情况

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