抗精神病治疗期间异常葡萄糖代谢的危险因素:一个前性队列研究
Takashi Miyakoshi1, Shuhei Ishikawa2, Ryo Okubo3
1Department of Health Data Science, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Journal of psychiatric research
|November 1, 2023
概括
某些抗精神病药物如奥兰扎,克洛扎和普罗马会增加高血糖的风险. 肥胖和高甘油三也提高了这种风险在精神分裂症,精神分裂症或双相情感障碍患者.
科学领域:
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗精神病药物与异常葡萄糖代谢的风险增加有关.
- 由于药物特异性和患者背景因素,预测这种风险具有挑战性.
- 确定特定的风险因素对于积极的患者管理至关重要.
研究的目的:
- 在接受抗精神病药物治疗的患者中,确定异常葡萄糖代谢进展的危险因素.
- 分析影响高血糖事件的药物相关和背景因素.
- 为治疗抗精神病患者的临床监测策略提供信息.
主要方法:
- 一个多中心的前性队列研究,涉及706名精神分裂症,精神分裂情绪障碍或双相情感障碍患者.
- 在基线排除糖尿病前期或可能患有糖尿病的患者.
- 时间依赖的考克斯回归分析以计算高血糖进展的危险比率.
主要成果:
- 奥兰扎 (HR=2.06),克洛扎 (HR=4.25) 和普罗马 (HR=4.48) 与高血糖症风险增加有关.
- 超重/肥胖 (HR=1.57) 和高三糖血 (HR=1.72) 显著增加了高血糖进展的风险.
- 抗精神病药物的数量和每日剂量与高血糖的发生没有相关性.
结论:
- 奥兰扎,克洛扎和普罗马需要仔细监测葡萄糖代谢.
- 患有肥胖或高三糖血症的患者需要对不正常的葡萄糖代谢进行警监测,无论抗精神病类型如何.
- 风险分层有助于个性化监测抗精神病药物的不良代谢影响.
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