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在重度抑郁症中,与特征和状态重复的负面思维相关的乳头皮质电路与主要抑郁症相关

Aki Tsuchiyagaito¹, Masaya Misaki², Gabe Cochran³

¹Laureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK, USA; Research Center for Child Mental Development, Chiba University, Chiba, Japan.

Journal of psychiatric research

|November 1, 2023

概括

在主要抑郁症中,重复的负面思维与右丘脑和前额叶皮层的异常连接有关. 这一发现可能会为未来的抑郁症神经调节治疗提供信息.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经成像是一种神经成像.

背景情况:

重复的负面思维 (RNT) 或反思是主要抑郁障碍 (MDD) 的关键症状,与糟糕的结果和自杀倾向有关.
RNT的跨诊断性质表明与痴迷共享的神经生物学机制,特别是涉及皮层-皮层-胸膜-皮层 (CSTC) 电路.

研究的目的:

为了研究MDD中RNT的神经生物学基质.
测试MDD中的RNT是否与痴迷共享大脑机制,重点关注CSTC电路.

主要方法:

功能性磁共振成像 (fMRI) 用于在RNT诱导过程中研究39名MDD患者.
测量了特征-RNT (食反应量表) 和状态-RNT (视觉模拟量表).
连接体全方位的关联分析检查了RNT强度与条状和thalamic连接性的联系.

主要成果:

较高的特征-RNT与右侧中背丘脑和前额叶皮层,韦尼克区域和后部默认模式网络之间的超连接相关.
较高状态的RNT与右侧背侧丘脑与感觉运动皮层,补充运动区域和布罗卡区域之间的超连接性相关.
没有发现与条纹连接性有显著的关联.

结论:

在MDD中,RNT涉及与认知和内脏处理相关的右丘脑核和皮质区域之间的异常连接.
深层大脑神经调节技术可以探索右丘脑皮质电路功能障碍和MDD中的RNT之间的因果关系.

关键词:

皮层 - 状 - 甲状腺 - 皮层电路.抑郁症抑郁症抑郁症功能连接性的功能连接性.重复的负面思维是重复性的.化化化化泰拉姆斯 (thalamus) 是一个神经元.

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