怀孕期间母亲的炎症与10岁儿童患ADHD的风险有关
Julie B Rosenberg1, Jens Richardt Møllegaard Jepsen2, Parisa Mohammadzadeh1
1Center for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark; Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
产前母亲炎症,通过高灵敏度C反应蛋白 (hs-CRP) 测量,与儿童注意力缺陷/多动症障碍 (ADHD) 的风险增加有关. 这一发现强调了炎症作为改善神经发育结果的潜在目标.
科学领域:
- 神经发育障碍 神经发育障碍
- 产前编程 在产前编程.
- 怀孕期间的炎症标志物
背景情况:
- 怀孕期间母亲的炎症被假设会影响后代的神经发育.
- 临床证据将产前炎症与儿童后期神经发育障碍 (如ADHD) 联系在一起是有限的.
- 之前的研究表明,从临床前和注册数据来看,存在潜在的关联.
研究的目的:
- 调查怀孕期间母亲的炎症水平与后代被诊断患有多动症的风险之间的联系.
- 检查母亲炎症与10岁儿童ADHD症状严重程度之间的关系.
- 评估产前炎症作为ADHD风险因素的临床相关性.
主要方法:
- 在COPSAC2010队列中对700对母婴对进行前性研究,从怀孕第24周开始进行跟踪.
- 孕妇高灵敏性C反应蛋白 (hs-CRP) 水平测量在妊娠24周.
- 儿童在10岁时接受了神经发育评估,包括ADHD诊断 (K-SADS-PL) 和症状负荷 (ADHD-RS),并对混因素进行了调整.
主要成果:
- 共有604名儿童 (86%) 参与了10岁儿童的评估.
- 较高的母体hs-CRP水平与ADHD诊断的风险增加显著相关 (OR1.40,p=0.001).
- 增加的母体hs-CRP也与儿童的ADHD症状负载 (ADHD-RS得分) 更高相关.
结论:
- 由hs-CRP指出的产前母亲炎症与10岁时的ADHD诊断有着强烈的关联.
- 怀孕期间母亲的炎症也与ADHD症状严重程度的维度方面有关.
- 识别炎症作为标记物为产前干预提供了潜在的目标,以改善神经发育结果.
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