使用废水监测对抗抗生素耐药性:意义,应用,挑战和未来方向
Sahar Gholipour1, Zahra Shamsizadeh2, Dariusz Halabowski3
1Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
The Science of the total environment
|November 1, 2023
概括
废水监测 (WS) 提供了一种具有成本效益的方法来跟踪社区的抗生素耐药性 (AR),作为公共卫生风险的早期预警系统. 尽管存在诸如标准化等挑战,但WS显得有前途,特别是在资源有限的环境中.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生监督是对公共卫生的监督.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 全球抗生素耐药性 (AR) 和耐药性感染的增加需要先进的监测.
- 废水监测 (WS) 是监测社区AR和公共卫生风险的未充分利用的工具.
- 目前对AR的WS的审查是有限的,强调需要进行全面分析.
研究的目的:
- 审查废水监测的原则,机会和限制,以了解抗生素耐药性.
- 在废水分析的背景下讨论当前和新兴的AR检测方法.
- 展示实证证据和WS在公共卫生决策中的未来前景.
主要方法:
- 关于对抗生素耐药性的废水监测现有文献的综述.
- 讨论各种AR检测方法及其对废水的适用性.
- 分析展示废水监测有用性的案例研究.
- 识别该领域的局限性和知识差距.
主要成果:
- 废水监测提供了诸如低成本,广泛覆盖,最小设备需求和早期发现健康威胁等优点.
- 有证据将废水AR与社区AR联系起来,支持其在公共卫生中的作用.
- 在缺乏诊断基础设施的低收入环境中,WS特别有价值.
结论:
- 废水监测是监测抗生素耐药性和为公共卫生战略提供信息的有希望的,具有成本效益的工具.
- 解决标准化,临床实用性和数据解释等挑战对于最大限度地发挥WS潜力至关重要.
- 需要对生物传感器,协议,试点研究和分析工具进行进一步的研究,以推进WS应用.
相关概念视频
00:57Antibiotic Selection
54.4K
Overview
54.4K
01:26Urine Studies II: Urine Culture and Sensitivity Test
36
A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
36
01:30Development of Antibiotic Resistance
17
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
17
01:28Gene Regulation in Microbial Communities: Quorum Sensing
23
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
23
01:28Biological Methods for Microbial Control
35
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
35