核心休息状态网络的连接模式与晚年抑郁症中的冷漠有关
Jean-Charles Roy1, Thomas Desmidt2, Sébastien Dam2
1From the Centre Hospitalier Guillaume Régnier, Pôle Hospitalo-Universitaire de Psychiatrie Adulte, Rennes, France (Roy, Mirea-Grivel, Louise, Drapier, Batail, Robert); the Centre d'investigation clinique (CIC) de Rennes 1414, CHU de Rennes, Institut national de la santé et de la recherche médicale (INSERM), Rennes, France (Roy, Drapier, Batail, Robert); l'Université de Rennes, Inria Centre, Centre National de la Recherche Scientifique, IRISA, INSERM, Empenn U1228 ERL, Rennes, France (Roy, Dam, Bannier, Coloigner, Robert); the Service de Radiologie, CHU Rennes, Rennes, France (Bannier); the CHU de Tours, Tours, France (Desmidt, Barantin); the UMR 1253, iBrain, Université de Tours, INSERM, Tours, France (Desmidt, Barantin); the CIC 1415, CHU de Tours, INSERM, Tours, France (Desmidt); the CoBTeK (Cognition Behaviour Technology) Lab, University Côte d'Azur, Nice, France (David) jc.roy@ch-guillaumeregnier.fr.
晚年抑郁症中的冷漠与对目标导向行为至关重要的网络中大脑连接的改变有关. 这些发现突显了老年抑郁症患者冷漠的神经基础.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 漠不关心是晚年抑郁症 (LLD) 的常见症状,与治疗结果较差和痴呆风险增加有关.
- 在LLD中无动于衷的神经基础仍然未被充分探索.
- 这项研究调查了与LLD中的冷漠相关的功能性大脑连接.
研究的目的:
- 检查休息状态网络 (RSN) 的功能连接,与LLD患者的冷漠相关.
- 在不同的测量尺度上识别特定的RSN和与冷漠相关的大脑区域.
主要方法:
- 休息状态功能性MRI数据从39名LLD患者和26名健康的老年人中获得.
- 通过使用冷漠的诊断标准 (DCA),冷漠评估量表 (AES) 和冷漠动机指数 (AMI) 来评估冷漠.
- 基于网络的统计数据确定了具有连接性的子网络,与冷漠度指标有显著的关联.
主要成果:
- 与对照人群相比,患有LLD的个体在默认模式,环眼眼和前面双眼网络中表现出改变的RSN内部和RSN间连接.
- 这三个冷漠度指标都与这些网络内的连接性发生变化相关,具体指标有所不同.
- AMI和AES显示了与特定网络的明显关联,这表明冷漠度维度的不同神经相关性.
结论:
- 在LLD中,冷漠始终与参与目标导向行为的RSN中功能连接的改变有关.
- 这些发现支持先前关于严重LLD中功能性RSN连接中断的研究.
- 这项研究强调了研究大脑网络变化的重要性,以了解和潜在地治疗LLD中的冷漠.
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