40岁以上成年人抗生素与喘风险之间的关联:全国代表性的回顾性队列研究
Jiwon Choi1,2, Sun Jae Park1, Young Jun Park3
1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, The Republic of Korea.
BMJ open respiratory research
|November 1, 2023
概括
成年人使用抗生素与患喘的风险较高有关,持续时间较长和更多类型的抗生素增加了这种风险. 这凸显了成年人群中明智的抗生素管理的重要性.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿童抗生素暴露与喘有关.
- 成年人使用抗生素和喘风险之间的关联尚未得到充分证实.
研究的目的:
- 调查抗生素使用与成人喘风险之间的关联.
主要方法:
- 使用国家医疗保险服务数据 (2005-2019) 的回顾性队列研究.
- 包括248,961名年龄≥40岁的成年人.
- 评估抗生素暴露 (持续时间,类别) 和使用考克斯回归的喘诊断.
主要成果:
- 抗生素使用≥91天增加了喘风险 (aHR1.84).
- 使用4个或以上的抗生素类别,与1个抗生素类别相比,增加了喘风险 (aHR1.44).
- 在抗生素暴露时间/类和喘风险之间观察到剂量依赖的关系.
结论:
- 成年人使用抗生素和喘风险增加之间存在明显的持续时间-反应关系.
- 研究结果表明,需要对成年人进行适当的抗生素使用和管理策略.
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