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在大鼠的口服和直肠管理之间比较柏柏林的生物利用性

Nobuhiro Mori1, Keisuke Oda1, Hideki Takakura1

  • 1Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University.

Biological & pharmaceutical bulletin
|November 1, 2023
PubMed
概括

与口服剂量相比,Berberine硫酸盐在老鼠中通过直肠给药显著提高了生物可用性. 这种直肠路由绕过了第一通代谢,改善了柏柏林的作用.

关键词:
柏柏林氨酸是一种柏柏林氨酸.生物可用性 生物可用性第一次通过新陈代谢.通过口服进行口服管理.鼠标 鼠标 鼠标 鼠标 鼠标通过直肠给药.

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