Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Gene Families01:57

Gene Families

8.8K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.8K
Inorganic Nitrogen Assimilation01:22

Inorganic Nitrogen Assimilation

22
Nitrogen is an essential element in biological systems, forming a crucial component of proteins, nucleic acids, and other cellular constituents. Many bacteria and archaea acquire nitrogen in the form of nitrate (NO₃⁻) or ammonia (NH₃), which are then assimilated into biomolecules through specific enzymatic pathways.Assimilatory Nitrate ReductionWhen nitrate enters the cell, it undergoes a two-step reduction process known as assimilatory nitrate reduction. Initially, the enzyme...
22
Protein and Protein Structure02:15

Protein and Protein Structure

79.6K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
79.6K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.8K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.8K
Overview of Myosin Structure and Function01:15

Overview of Myosin Structure and Function

4.4K
Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X)  have been well...
4.4K
Hemoglobin01:24

Hemoglobin

3.6K
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
3.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CHK1 as a Metabolic and Immunological Regulator: Implications for Cancer Therapy.

Oncology research·2026
Same author

The [2Fe2S] cluster and active-site architecture of Corynebacterium diphtheriae coproporphyrin ferrochelatase: Structure, stability, and catalysis.

International journal of biological macromolecules·2026
Same author

Human neuroglobin and H64A distal variant: How mutation and pH affect the heme pocket.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Genetic diversity hotspot at the edge of the species range: integrating plastome phylogeography with ecological niche modelling for the conservation of Ulmus glabra Huds. in the Italian peninsula.

BMC plant biology·2025
Same author

Structural Instability of Human Serum Albumin during Microparticles Synthesis.

ACS applied bio materials·2025
Same author

Proton-linked effects on the axial coordination in ferric and ferrous horse heart cytochrome c.

Protein science : a publication of the Protein Society·2025

相关实验视频

Updated: Jul 12, 2025

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
07:19

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Published on: July 29, 2021

2.4K

尼特罗宾丁与肌球蛋白:一个比较的结构和功能研究.

Giovanna De Simone1, Alessandra di Masi1, Andrea Pasquadibisceglie1

  • 1Dipartimento di Scienze, Università Roma Tre, 00146 Roma, Italy.

Journal of inorganic biochemistry
|November 1, 2023
PubMed
概括
此摘要是机器生成的。

这项研究比较了全α-螺旋型肌球蛋白和全β-桶型基结合蛋白的独特结构和功能性质,揭示了对血红蛋白多样性和氧和氧化信号传递中的潜在作用的见解.

关键词:
功能 功能 功能 功能骨髓蛋白质是什么 骨髓蛋白质是什么亚酸丁丁是什么意思在RNS和ROS排毒过程中,RNS和ROS排毒.频谱学性质 频谱学性质结构 结构 是一个结构.

更多相关视频

Nitropeptide Profiling and Identification Illustrated by Angiotensin II
07:31

Nitropeptide Profiling and Identification Illustrated by Angiotensin II

Published on: June 16, 2019

5.7K
A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
10:28

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors

Published on: August 17, 2019

9.6K

相关实验视频

Last Updated: Jul 12, 2025

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements
07:19

Preparation of Rat Skeletal Muscle Homogenates for Nitrate and Nitrite Measurements

Published on: July 29, 2021

2.4K
Nitropeptide Profiling and Identification Illustrated by Angiotensin II
07:31

Nitropeptide Profiling and Identification Illustrated by Angiotensin II

Published on: June 16, 2019

5.7K
A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors
10:28

A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors

Published on: August 17, 2019

9.6K

科学领域:

  • 生物化学 生物化学
  • 结构生物学 结构生物学
  • 蛋白质科学 蛋白质科学

背景情况:

  • 大多数血液蛋白都具有全α螺旋 (例如,肌球蛋白),对于气体运输和排毒至关重要.
  • 尼特罗宾丁 (Nbs) 是一种独特的类型的血红蛋白,具有全β-桶折叠,在各种物种中被确定.
  • 虽然Nbs的功能在很大程度上是未知的,但它们可能参与O2/NO信号传递和新陈代谢.

研究的目的:

  • 为了比较肌球蛋白 (Mb) 和尼特罗宾丁 (Nbs) 的结构,光谱和功能特征.
  • 阐明全α螺旋和全β桶血红蛋白之间的相似之处和差异.
  • 探索Nbs在生理过程中的潜在作用,特别是在视网膜等对氧敏感组织中.

主要方法:

  • 对 Mb 和 Nbs. 的结构数据进行比较分析.
  • 两类蛋白质的光谱表征.
  • 通过实验研究评估功能性质.

主要成果:

  • 血蛋白表现出多样化的折叠,包括经典的α-螺旋环球蛋白折叠和不太常见的Nbs.的β-桶折叠.
  • Nbs是十条链抗平行β-桶血蛋白,在O2/NO信号传递中具有潜在的作用.
  • 了解这些差异对于理解各种生物环境中的血红蛋白功能至关重要,包括疾病状态.

结论:

  • 尼特罗宾丁代表了与公认的α-螺旋式血蛋白结构的显著偏离.
  • 对Nbs的功能进行进一步的研究可能会揭示氧和氧化调节的新机制.
  • 这项比较研究加深了我们对血红蛋白演变和功能的理解,对玻璃眼和糖尿病视网膜病变等疾病有影响.