西班牙脏贫血的流行病学和治疗:RIKAS回顾性研究
Aleix Cases1, Elena González de Antona Sánchez2, Giovanna Cadeddu2
1Departament de Medicina, Universitat de Barcelona, Barcelona, Spain; Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Grupo de Anemia de la S.E.N., Spain.
Nefrologia
|November 1, 2023
概括
贫血影响了超过三分之一的慢性病的成年人没有透析,超过90%的透析在西班牙. 铁含量往往不足,这表明需要改善慢性病患者的贫血管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 血液学 血液学 血液学
- 流行病学 流行病学
背景情况:
- 贫血是慢性病 (CKD) 的常见并发症.
- 之前在西班牙对CKD相关贫血的研究已经过时或范围有限.
- 需要目前的流行病学数据和西班牙CKD贫血的治疗模式.
研究的目的:
- 确定西班牙慢性病患者贫血的当前流行病学.
- 评估CKD患者贫血的当代治疗模式.
- 为了评估贫血慢性病患者的铁状况.
主要方法:
- 一个多中心的,非干预的,回顾性研究 (RIKAS研究).
- 包括非透析 (CKD-ND) 3a-5阶段的CKD患者和透析 (CKD-D) 的CKD患者.
- 在2015年至2017年期间在西班牙收集的数据.
主要成果:
- 2015年,贫血患病率在CKD-ND中为33.8%,在CKD-D中为91.5%.
- 贫血性CKD患者的系统性炎症更高,特别是那些服用红色素形成刺激剂 (ESA) 患者.
- 贫血患者的铁参数 (费里丁,TSI) 通常低于推指南.
结论:
- 贫血和炎症的患病率随着CKD严重程度的增加而增加,特别是透析患者的患病率更高.
- 无论是否在ESA上,贫血的CKD患者的铁管理需要改进.
- 在西班牙,对慢性病患者的贫血治疗策略有很大的潜力.
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