内在机制对人体中鼻腔节点功能的年龄相关贡献
Ido Weiser-Bitoun1,2, Hitoshi Mori3, Taisuke Nabeshima3
1Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Scientific reports
|November 2, 2023
概括
自主神经系统和内在机制会随着年龄的增长不同地影响心率的变化. 麻醉影响这些机制,其内在机制特征仅可从节拍间隔计算.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统研究 自主神经系统研究
- 心脏电生理学 心脏电生理学
背景情况:
- 心率的变化受自主神经系统 (ANS) 和节点 (SAN) 内在机制的影响.
- 观察到与年龄相关的内在心率下降,但ANS和内在机制在SAN功能障碍中的作用尚不清楚.
- 了解这些贡献对于管理与年龄有关的心血管变化至关重要.
研究的目的:
- 在不同年龄组中区分ANS和内在机制的贡献,以击败区间变化 (BIV).
- 评估麻醉对ANS和内在心脏机制的影响.
- 为了识别可从节拍间隔中得出的内在机制特征,而无需干预.
主要方法:
- 电心电图 (ECG) 记录来自年轻 (<21岁) 和成年 (41-78岁) 患者.
- 测量是在基底状态和自主阻塞 (propranolol,atropine) 后在麻醉 (propofol,dexmedetomidine) 下进行的.
- 节拍间隔 (BI) 和BIV数据被分析,使用特定特征来识别ANS,内在和麻醉特征.
主要成果:
- 在年轻患者中,内在机制主要影响了长期BIV,而ANS影响了短期BIV.
- 在成年人中,ANS和内在机制都对短期BIV产生了影响,而内在机制也影响了长期BIV.
- 麻醉在年轻患者中调节了ANS功能,在成人中调节了ANS和内在机制.
结论:
- 随着年龄的增长,ANS和内在机制对BIV的相对贡献会发生变化.
- 麻醉显著影响年轻和成人患者的心脏调节机制.
- 从节拍间隔数据中可靠地提取内在心脏机制特征,提供一种非侵入性评估方法.
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