克洛托与认知和痴呆症的关系:来自NHANES 2011-2014和门德尔随机化研究的结果
Yue Wu1,2, Shaoyuan Lei2, Dongxiao Li1
1Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
Translational psychiatry
|November 2, 2023
概括
克洛托水平与老年人的认知功能有积极的关联. 然而,门德尔的随机化研究没有发现Klotho与痴呆风险之间的因果关系.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 老年学是一门学科.
背景情况:
- 克洛托蛋白水平与包括痴呆症在内的认知衰退之间的关系尚不清楚.
- 了解这种关联对于开发针对年龄相关认知障碍的干预措施至关重要.
研究的目的:
- 调查血清Klotho度与老年人认知功能之间的关联.
- 通过使用孟德尔随机化 (MR) 来确定Klotho水平和痴呆症之间的潜在因果关系.
主要方法:
- 从NHANES (2011-2014) 采用数字符号替换测试 (DSST) 进行认知评估,对1875名60-79岁的成年人进行横截面分析.
- 权重多变量调整的线性回归来评估Klotho-认知关联.
- 两个样本的孟德尔随机化 (MR) 使用逆方差加权 (IVW) 方法来评估Klotho和痴呆类型 (阿尔茨海默氏症,血管,前,莱维体) 之间的因果关系.
主要成果:
- 在血清Klotho度和DSST得分之间观察到显著的积极关联,表明Klotho水平较高的认知功能更好.
- 还注意到了Klotho和DSST之间可能存在的非线性关系.
- 核磁共振分析显示,基因预测的Klotho水平与任何形式的痴呆症 (阿尔茨海默氏症,血管,前或勒维体痴呆症) 之间没有显著的因果关系.
结论:
- 虽然Klotho水平与老年人的认知功能有交叉相关,但遗传证据不支持Klotho在痴呆症发展中的因果作用.
- 需要进一步的研究,以阐明克洛托对认知的影响的复杂机制及其在痴呆病原体中的潜在作用.
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