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Updated: Jul 12, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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通过调节STING激活和循环循环,ARF1可以防止异常的I型干扰素诱导

Maximilian Hirschenberger1, Alice Lepelley2, Ulrich Rupp3

  • 1Institute of Molecular Virology, Ulm University Medical Center, 89081, Ulm, Germany.

Nature communications
|November 2, 2023
PubMed
概括

ADP-ribosylation factor 1 (ARF1) 突变破坏了I型干扰素 (IFN) 的信号调节. 这导致IFN活性增强,并通过影响线粒体完整性和STING蛋白回收而产生新型干扰性.

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